• SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1, 6-DIHYDRO PYRIDINE DERIVATIVES
Abstract
The 2-amino-4-ethyl-1,6-dihydro 6-thiophenyl pyridine-3,5- dicarbonitriles were synthesized within a single step using aldehydes, active methylene compounds and thiophenol in ethanol and piperidine system. The synthetic potential of the method was to be investigated to obtain its 4-substituted and 6-substituted derivatives. In view of this the prior method was optimized and the desired 4-sustituted and 6-substituted compounds were synthesized with 60-90% yield. Newly synthesized compounds were found to have antifungal and antihistaminic activity.
Keywords
Full Text:
PDFRefbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
© 2012-2021 IJPA Copyright Agreement & Authorship Responsibility |