• SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 5, 5-DIPHENYL N (3)-SUBSTITUTED IMIDAZOLIDINE 2, 4-DIONE DERIVATIVES
Abstract
A Convenient high yield synthesis of pharmaceutically interesting 5,5-diphenyl N(3)-substituted imidazolidine 2,4-dione derivatives from benzil and urea is described. The structures of compounds were established on the basis of IR,NMR and GC-MS spectral data. The title compounds were investigated for anti-inflammatory and antibacterial activity. The tested compounds exhibited good antiinflammtory and antibacterial activity as compared to standard drugs. The 5,5-diphenyl imidazolidine dione was generated from the condensation between benzil and urea and then converted to the desired derivatives by condensation with aryl compounds.
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