• SCREENING OF HEPATOPROTECTIVE POTENTIAL OF ETHANOLIC AND AQUEOUS EXTRACT OF TERMINALIA ARJUNA BARK AGAINST PARACETAMOL/CCL4 INDUCED LIVER DAMAGE IN WISTAR ALBINO RATS

Abstract

Screening hepatoprotective potential of ethanolic and aqueous extract of Terminalia arjuna bark against paracetamol/ CCl4 induced liver damage in wistar albino rats. Hepatotoxicity was induced by paracetamol/CCl4 and the biochemical parameters such as serum glutamic pyruvic transaminase (sGPT), serum glutamic oxaloacetic transaminase (sGOT) and serum alkaline phosphatase (sALP), serum bilirubin (SB) and histopathological changes in liver were studied along with silymarin as standard hepatoprotective agents. The phytochemical investigation of the extracts showed presence of alkaloids, glycosides, steroids and flavonoids, saponin, tanins. Pre-treatment of the rats with ethanol and aqueous extract prior to paracetamol/CCl4 administration caused a significant reduction in the values of sGOT, sGPT, sALP and sB almost comparable to the silymarin. The hepatoprotective was confirmed by histopathological examination of the liver tissue of control and treated animals. From the results it can be concluded the Terminalia arjuna possesses hepatoprotective effect against paracetamol/CCl4 -induced liver damage in wistar albino rats.