• RECENT TRENDS OF NOVEL DRUG DELIVERY IN TREATMENT OF DIABETIS MELLITUS

Abstract

Diabetes mellitus is a metabolic disorder, characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. The effects of diabetes mellitus include long-term damage, dysfunction and failure of various organs. Although the availability of new agents for treatment of diabetes mellitus, oral hypoglycemic are base of therapy, because they are relatively economical and well tolerated. A well designed controlled drug delivery system can overcome some of the inconvenience of conventional therapy and enhance the therapeutic efficacy of a given drug. This review article discusses the potential applications of novel drug delivery systems (NDDS) for diabetes treatment. NDDS includes microspheres, nanoparticles, niosomes, proniosomes etc., which are preferably used in treatment of this disease. There are a few limitations in the use of conventionally available drug delivery systems. Lack of target specificity, altered effects and diminished potency due to drug metabolism in the body, cytotoxicity of certain anti- carcinogenic pharmacological agents, are to mention a few. Biocompatible nanoparticles with optimized physical, chemical and biological properties can overcome these limitations and serve as effective drug delivery systems. These newer generations of drug delivery systems have significant advantages over conventionally available drug delivery systems.