• PREPARATION AND CHARACTERIZATION OF ACETAZOLAMIDE HYDROXY PROPYL- β-CYCLODEXTRIN COMPLEXES PREPARED BY KNEADING METHOD USED IN OCULAR DRUG DELIVERY

Abstract

Purpose: Enhancement of the solubility and dissolution of acetazolamide using inclusion complex with HP β-cyclodextrin and polyvinyl alcohol by kneading technique.

Methods: Acetazolamide inclusion complexes were prepared using physical mixture method and kneading method. Powder X- RD, Infrared (IR) spectroscopy and Differential Scanning Calorimetry (DSC) were performed to identify physiochemical interaction between the drug and carrier and its effect on dissolution behavior. Morphology of the Inclusion complex was studied using Scanning Electron Microscopy (SEM). A comparative evaluation of the dissolution of acetazolamide-HP-β-CD- PVA inclusion complex, physical mixture and pure drug was carried out.

Results: Dissolution of Aceatzolamide (ACZ) improved significantly in inclusion complex as compared to pure drug and physical mixtures. ACZ exhibited better aqueous solubility in presence of both HP-β-CD and PVA. The percentage of ACZ dissolved after 90 min was 48.98%, for pure drug compared with 98.42% for the drug in inclusion complex. IR spectroscopy showed no change in chemical structure of ACZ. Conclusions: Inclusion complex technique of solid dispersion by kneading method can be successfully used for improvement of dissolution of acetazolamide.