• EFFECTS OF SYZYGIUM AROMATICUM AND ROSADAMASCENAIN OXIDATIVE STRESS ACTIVITY ON DIABETES INDUCED RATS

Abstract

A common complication of diabetes is impaired oxidative stress systemic Syzygium aromaticum and Rosadamascena essential oil improves oxidative stress in diabetic model and the effect of essential oil wereexamined. Streptozotocin (60mg/kg body weight) induced diabetic rats, treatment of diabetic rats with Syzygium aromaticum (200 µl/kg) and Rosadamascenaoil (200µl/kg.) for 15 days analysis carried out in antioxidants methods: Lipid peroxides, nitric oxide, Total thiols, Superoxide dismutase, Ceruloplasmin, Albumin, Uric acid. Erythrocytes lysate, Lipid peroxides, Total thiols, Superoxide dismutase, Glutathione s- transferase, Catalase. Tissue homogenates methods, Lipid peroxides, Total thiols, Superoxide dismutase, Glutathione s- transferase, Catalase. andhistopathological study analysis. The results suggest that Syzygium aromaticumoil and Rosadamascena oil may effectively normalize the impaired antioxidants status in streptozotocin induced-diabetes. The effects of these antioxidants of both agents may be useful in delaying the complicated effects of diabetes as retinopathy, nephropathy and neuropathy due to imbalance between free radicals and antioxidant systems. Moreover, Rosadamascena oil may be more powerful free radical scavenger than Syzygiumaromaticumoil.