• FORMULATION AND EVALUATION OF ORO DISPERSIBLE TABLETS OF LORNOXICAM

Abstract

Orodispersible tablets are the fast growing and highly accepted drug delivery system in now a day mainly to improve patient compliance. Orodispersible tablets have number of advantages over conventional dosage forms, because of that Orodispersible tablets have emerged as an alternative to conventional dosage forms. Lornoxicam is a non steroidal anti-inflammatory drug with analgesic properties and belongs to the class oxicams. Orodispersible tablets of Lornoxicam were prepared using superdisintegrants viz; crospovidone, croscarmellose sodium and sodium starch glycolate using the direct compression method. The tablets prepared were evaluated for thickness, uniformity of weight, hardness, friability, wetting time, in vitro disintegration time and in vitro dissolution time. The different formulations showed disintegration time between 20 to 36 s. Drug release showed time between the range upto 45 min.  Among all the formulations, F3 (containing 5% of crospovidone) showed 99% drug release within 45 min and it showed least disintegration time. Thus, F3 was considered best among the other formulations. The stability study was conducted as per the ICH guidelines and the  optimized formulation (F3) was found to be stable, with insignificant change in hardness, drug content and disintegration time. Therefore the main objective of the present work is to develop orodispersible tablets of Lornoxicam to improve bioavailability, disintegration time, dissolution efficacy and patient compliance.