• SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 5, 5-DIPHENYL N (3)-SUBSTITUTED IMIDAZOLIDINE 2, 4-DIONE DERIVATIVES

Abstract

A Convenient high yield synthesis of pharmaceutically interesting 5,5-diphenyl N(3)-substituted imidazolidine 2,4-dione derivatives from benzil  and urea is described. The structures of compounds were established on the basis of IR,NMR and GC-MS  spectral data. The title compounds were investigated for anti-inflammatory and antibacterial activity. The tested compounds exhibited good antiinflammtory and antibacterial activity as compared to standard drugs. The 5,5-diphenyl imidazolidine dione was generated from the condensation between benzil and urea and then converted to the desired  derivatives by condensation with aryl compounds.