• IMPROVED ANTICANCEROUS ACTIVITY OF INDIAN ALOE LOADED CHITOSAN MICROSPHERES

Abstract

Indian Aloe-Vera is gift of nature and been blessed with versatile medicinal purposes. The study has been designed for the assessment of the In-Vitro anticancer activity of Indian aloe when loaded in Targeted drug delivery system i.e., microspheres. MTT assay method was employed for the investigation of in-vitro anticancerous activity. The human cancer cell lines HepG2, HT-29 and PC-3 for its effects on cell viability, growth inhibition was significantly distorted by the extract of aloe loaded in targeted drug delivery system. A considerable decline of the number of cancer cell and tumor influence was observed in the in-vitro tumor induced media. The study shows that when the extract of aloe was loaded in suitable targeted drug delivery system exhibits the significant survival time of drug in targeted area due to sustained release of microspheres, non viable cell count and decrease the viable count of cancerous cell.