• EFFECT OF DIFFERENTIAL SERUM LIPID DISTRIBUTION ON THE HYPERTENSIVITY STATUS OF PATIENTS OF NORTH EAST INDIA: A CLINICAL STUDY AS A GUIDELINE FOR PREVENTION OF CARDIAC MYOPATHY

Abstract

The present study elucidates effect of different lipid fractions in the serum to evaluate their role in hypertensivity of patients and ultimately as a parameter for the causation of cariac myopathy or other cardiovascular disturbances. Tthe serum lipid profile viz the level of total cholesterol (TC =, 196.10 ± 8.28 (166 – 268), Triglyceride (TG=179.63 ± 14.35 (166- 240), HDL-cholesterol=(33.43 ± 6.85 (21 -43) and LDL-cholesterol = (132.20 ± 4.49 (67 –119) of hypertensive patients was compared with the levels of control subjects TC=149.5 ± 2.06 (130-168 ),. (TG= 138.51± 5.14 (80 -225), HDL-cholesterol= 35.46 ± 0.65 (21 – 43), LDL-cholesterol =95.60 ± 3.46 (67-119)) respectively. The results revealed that serum total cholesterol, triglyceride and LDL-cholesterol were significantly markedly raised (p<0.001) whereas the level of HDL-cholesterol was significantly lower (p<0.001) in hypertensive patients as compared to control subjects. The higher level of serum TC, TG and LDL-cholesterol in the study population may be due to genetic factors and increased consumption of dietary animal fat, lack of physical exercise, metabolic disorders like diabetes Mellitus and hypothyroidism, severe stress, increased age, sex as well as alcohol and tobacco consumption may also be the contributory factors for this phenomenon. It was concluded that hypercholesterolaemia, hypertrigyceridaemia and low density lipoprotein are the main lipid abnormalities on the incidence of hypertension in the study area. serum Lipid profile can be easily maintained to near normal level to prevent hypertension and cardiovascular diseases. Thus, the study indicates the role of lipid fractions and hypertensivity as public health preventive indicative measure.