• DEVELOPMENT OF NEW COLORIMETRIC METHOD AND VALIDATION FOR DETERMINATION OF MELOXICAM IN BULK AND MARKETED FORMULATION

Raval Kashyap*, Barochiya Kaushal, Joshi Mohit, Bhusan kalavadiya

Abstract


In the present work, simple, sensitive, specific, and validated colorimetric method has been developed for the quantitative estimation of Meloxicam in bulk and pharmaceutical dosage form. Meloxicam in presence of acidic medium reacts with MBTH reagent and FeCl3 solution and gives yellow colour. The λmax was found to be 465nm for assay. The linearity was found in concentration range of 10-60µg/ml. The correlation coefficient was found 0.9854. The regression equation was found as Y= 0.0128X + 0.0171. The method was validated for linearity, accuracy, precision and ruggedness. The LOD and LOQ for estimation of Meloxicam was found as 0.3769, 1.1456 respectively. Recovery of Meloxicam was found to be 95.33%. Proposed method was successfully applied for the quantitative estimation of Meloxicam in marketed formulations.

Keywords


Meloxiam, MBTH reagent, FeCl3, 0.1N NaCl and distilled water.

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