• PREPARATION AND EVALUATION OF BETAMETHASONE DIPROPIONATE CREAM: MULTI EMULSION A NOVEL APPROACH
Abstract
Betamethasone dipropionate cream was prepared by using multiple emulsion technique. Cream was characterized for determination of pH, drug content uniformity, viscosity, spreadibility, tube extrudability, stability studies, in-vitro drug release, infrared spectral analysis, primary skin irritation test on laboratory experimental animals. The pH of formulations was found to be 6.1-6.3. Viscosity was determined by Brookefield viscometer and the non-newtonian flow was observed. The cream when applied to skin was able to spread easily on surface. The cream was extruded easily from the tube. The stability studies was carried out for a period of one month and analyzed for physical appearance, rheological properties which were found to be effective. From the IR spectral analysis, it was found that there is no major shifting of peaks confirming no drug excipient interactions. A skin irritation study for the prepared cream was done on animals which showed non-irritant effect on skin. From the study it may be revealed that betamethasone dipropionate multiple emulsion cream formulation should be useful for treatment of skin psoriasis, can be easily washed by water with increased patient compliance.
Keywords
Full Text:
PDFRefbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
© 2012-2021 IJPA Copyright Agreement & Authorship Responsibility |