• SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 5-METHYL-N-ARYL SUBSTITUTED OXAZOLIDINE DIONE DERIVATIVES

Abstract

A Convenient high yield one pot methodology for the synthesis of pharmaceutically interesting5-methyl-N-aryl substituted oxazolidine-2, 4-dione derivatives from 2-chloropropanamide is described. The structures of compounds were established on the basis of IR and NMR spectral data. The title compounds were investigated for antimicrobial activity. The tested compounds exhibited good antimicrobial activity as compared to standard drugs. The oxazolidine-2,4 dione was generated from the condensation between α-hydroxy ester and guanidine and then converted to the desired derivatives via aqueous acid hydrolysis, reflux condensation with aryl compounds.