• COMPARITIVE STUDY OF HYDROPHILLIC POLYMERS FOR SUSTAINED DRUG DELIVERY OF AN LAMIVUDINE

Abstract

The objective of the present study was to formulate and  evaluate  Lamivudine matrix tablets using hydrophilic polymers like  karayagum(K.R), kondagogu gum(K.G), and HPMC( K100) of different ratios 2.5%,5% and 7.5% were formulated by direct compression method. The formulated tablets were characterized for hardness, friability, drug content, tensile strength. In vitro drug release studies were carried out in pH 1.2 buffer for 2hrs and then in PH 6.8 phosphate buffer. The content uniformity was found to be within the compendial limits. FTIR revealed the absence of drug-polymer interaction. The rate of drug release was extended for more than 12 hours by the HPMC (K100).HPMC was able to sustain the drug release well when compared to gum karaya and gum kondagogu. The order of release for all the formulations fitted zero order except f7 formulation followed the first order release. Mechanism of drug release from all the formulations is non-fickian diffusion which refers to a combination of both diffusion and erosion controlled drug release.