• ACUTE AND SUB ACUTE TOXICITY STUDY ON SIDDHA DRUG ARUVAGAI CHOORANAM

Abstract

Hypertension is the most important preventable risk factor for premature death worldwide. Aruvagai chooranam(AC) is a traditional siddha medicine for the treatment hypertension. To evaluate safety profile of AC in rats under the OECD guidelines 423 and 407. Sub-acute toxicity studies, different doses of AC were administered orally to rats once daily for 28 consecutive days in various dose levels ranging from 40, 200 and 400 mg/kg. In acute toxicity, study of AC revealed no mortality, abnormal signs and behavioral changes in rats at the dose of 2000 mg/kg body weight administered orally. Histopathological analysis did not reveal any abnormal macroscopic changes in the vital organs. The AC was found to be safe in animals. No toxic effect was observed in acute and sub acute toxicity study of AC.